ACTR8

Entrez Summary: N/A
UniProt Summary: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.86
UM131593 0.2μM R03 exp106	-1.86
RO-3307 4.7μM R02 exp80	-1.76
Pterostilbene 16μM R02 exp78	-1.75
Rotenone 20μM R00 exp34	-1.71

Global Fraction of Cell Lines Where Essential: 413/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	17/28
blood	17/28
bone	11/25
breast	16/33
central nervous system	26/56
cervix	4/4
colorectal	10/17
esophagus	9/13
fibroblast	0/1
gastric	8/15
kidney	14/21
liver	11/20
lung	43/75
lymphocyte	7/14
ovary	16/26
pancreas	16/24
peripheral nervous system	11/16
plasma cell	10/15
prostate	1/1
skin	14/24
soft tissue	5/7
thyroid	1/2
upper aerodigestive	12/22
urinary tract	17/29
uterus	4/5

Expression Distribution

Ino80 complex
3-5 DNA helicase activity
ATP-dependent chromatin remodeling
DNA duplex unwinding
DNA geometric change
chromatin remodeling
double-strand break repair
DNA recombination
protein deubiquitination
protein modification by small protein removal
DNA conformation change
centrosome
cell division
DNA repair
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
chromosome organization
proteolysis
cell cycle
ATP binding
cellular response to stress