ACVR1C [The Human Chemical-Genetic Interaction Map Project]

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======= ACVR1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACVR1C
  * **<color #00a2e8>Official Name</color>**: activin A receptor type 1C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=130399|130399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NER5|Q8NER5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACVR1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACVR1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608981|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Activin recp|
|TGF beta GS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chorionic trophoblast cell proliferation|
|activin receptor activity, type I|
|regulation of chorionic trophoblast cell proliferation|
|negative regulation of trophoblast cell migration|
|nodal binding|
|activin receptor complex|
|transforming growth factor beta receptor activity, type I|
|regulation of trophoblast cell migration|
|nodal signaling pathway|
|activin binding|
|transforming growth factor beta-activated receptor activity|
|apoptotic nuclear changes|
|activin receptor signaling pathway|
|cellular component disassembly involved in execution phase of apoptosis|
|response to dietary excess|
|lipid storage|
|growth factor binding|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|SMAD binding|
|execution phase of apoptosis|
|negative regulation of reproductive process|
|negative regulation of hormone secretion|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of protein secretion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to glucose|
|negative regulation of peptide secretion|
|response to hexose|
|response to monosaccharide|
|positive regulation of cysteine-type endopeptidase activity|
|cellular response to transforming growth factor beta stimulus|
|regulation of reproductive process|
|response to transforming growth factor beta|
|maintenance of location|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of peptidase activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of secretion by cell|
|receptor complex|
|regulation of peptide hormone secretion|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to insulin|
|negative regulation of secretion|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of cell migration|
|regulation of hormone secretion|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|lipid localization|
|negative regulation of locomotion|
|positive regulation of proteolysis|
|protein serine/threonine kinase activity|
|response to peptide hormone|
|cellular component disassembly|
|regulation of endopeptidase activity|
|pattern specification process|
|regulation of peptidase activity|
|regulation of protein secretion|
|response to peptide|
|negative regulation of transport|
|regulation of peptide secretion|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to extracellular stimulus|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of secretion|
|regulation of cell migration|
|response to hormone|
|regulation of cell motility|
|apoptotic process|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|regulation of protein localization|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACVR1C Expression in NALM6 Cells: -2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>