ACVR1C

Gene Information

Official Symbol: ACVR1C
Official Name: activin A receptor type 1C
Aliases and Previous Symbols: N/A
Entrez ID: 130399
UniProt: Q8NER5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17067
Expression level (log2 read counts): -2.47

Expression Distribution

Pkinase Tyr
Pkinase
Activin recp
TGF beta GS

negative regulation of chorionic trophoblast cell proliferation
activin receptor activity, type I
regulation of chorionic trophoblast cell proliferation
negative regulation of trophoblast cell migration
nodal binding
activin receptor complex
transforming growth factor beta receptor activity, type I
regulation of trophoblast cell migration
nodal signaling pathway
activin binding
transforming growth factor beta-activated receptor activity
apoptotic nuclear changes
activin receptor signaling pathway
cellular component disassembly involved in execution phase of apoptosis
response to dietary excess
lipid storage
growth factor binding
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
SMAD binding
execution phase of apoptosis
negative regulation of reproductive process
negative regulation of hormone secretion
transforming growth factor beta receptor signaling pathway
negative regulation of protein secretion
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to glucose
negative regulation of peptide secretion
response to hexose
response to monosaccharide
positive regulation of cysteine-type endopeptidase activity
cellular response to transforming growth factor beta stimulus
regulation of reproductive process
response to transforming growth factor beta
maintenance of location
response to carbohydrate
positive regulation of endopeptidase activity
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization