ADAM22 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAM22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAM22
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase domain 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53616|53616]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0K1|Q9P0K1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAM22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAM22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603709|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pep M12B propep|
|Disintegrin|
|ADAM CR|
|Reprolysin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to postsynaptic specialization membrane|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|Schwann cell development|
|protein localization to postsynaptic membrane|
|Schwann cell differentiation|
|receptor localization to synapse|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|integral component of postsynaptic density membrane|
|protein localization to synapse|
|peripheral nervous system development|
|adult locomotory behavior|
|metalloendopeptidase activity|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|integrin binding|
|adult behavior|
|glial cell differentiation|
|locomotory behavior|
|gliogenesis|
|protein localization to cell periphery|
|protein-containing complex localization|
|negative regulation of cell adhesion|
|axon|
|glutamatergic synapse|
|protein localization to membrane|
|behavior|
|regulation of cell adhesion|
|protein localization to organelle|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|proteolysis|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.98|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.83|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8713
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAM22 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>