ADAM22

Entrez Summary: N/A
UniProt Summary: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein localization to postsynaptic specialization membrane
neurotransmitter receptor localization to postsynaptic specialization membrane
myelination in peripheral nervous system
peripheral nervous system axon ensheathment
Schwann cell development
protein localization to postsynaptic membrane
Schwann cell differentiation
receptor localization to synapse
regulation of postsynaptic membrane neurotransmitter receptor levels
integral component of postsynaptic density membrane
protein localization to synapse
peripheral nervous system development
adult locomotory behavior
metalloendopeptidase activity
myelination
glial cell development
axon ensheathment
ensheathment of neurons
integrin binding
adult behavior
glial cell differentiation
locomotory behavior
gliogenesis
protein localization to cell periphery
protein-containing complex localization
negative regulation of cell adhesion
axon
glutamatergic synapse
protein localization to membrane
behavior
regulation of cell adhesion
protein localization to organelle
cell adhesion
biological adhesion
central nervous system development
proteolysis
cellular protein localization
cellular macromolecule localization
neurogenesis
cell development