ADAMTS1

Entrez Summary: N/A
UniProt Summary: Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. {ECO:0000250, ECO:0000269|PubMed:10438512}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ovulation from ovarian follicle
heart trabecula formation
positive regulation of vascular associated smooth muscle cell migration
ovulation
regulation of vascular associated smooth muscle cell migration
trabecula formation
heart trabecula morphogenesis
positive regulation of vascular smooth muscle cell proliferation
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of smooth muscle cell migration
ovulation cycle process
trabecula morphogenesis
positive regulation of cell cycle G1/S phase transition
regulation of vascular smooth muscle cell proliferation
regulation of smooth muscle cell migration
metallopeptidase activity
ovulation cycle
positive regulation of mitotic cell cycle phase transition
positive regulation of smooth muscle cell proliferation
female gonad development
basement membrane
development of primary female sexual characteristics
positive regulation of cell cycle phase transition
integrin-mediated signaling pathway
metalloendopeptidase activity
female sex differentiation
cardiac chamber morphogenesis
female gamete generation
regulation of smooth muscle cell proliferation
regulation of G1/S transition of mitotic cell cycle
positive regulation of mitotic cell cycle
regulation of cell cycle G1/S phase transition
heparin binding
cardiac chamber development
gonad development
development of primary sexual characteristics
heart morphogenesis
cytoplasmic vesicle
sex differentiation
kidney development