ADAMTS12 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAMTS12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAMTS12
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase with thrombospondin type 1 motif 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81792|81792]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58397|P58397]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAMTS12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAMTS12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606184|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pep M12B propep|
|ADAM spacer1|
|TSP 1|
|Reprolysin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hepatocyte growth factor receptor signaling pathway|
|negative regulation of cellular response to hepatocyte growth factor stimulus|
|regulation of cellular response to hepatocyte growth factor stimulus|
|proteoglycan catabolic process|
|regulation of hepatocyte growth factor receptor signaling pathway|
|regulation of endothelial tube morphogenesis|
|negative regulation of cellular response to vascular endothelial growth factor stimulus|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|glycoprotein catabolic process|
|negative regulation of chondrocyte differentiation|
|negative regulation of cartilage development|
|regulation of chondrocyte differentiation|
|regulation of cartilage development|
|proteoglycan metabolic process|
|metalloendopeptidase activity|
|cellular response to BMP stimulus|
|response to BMP|
|cell-matrix adhesion|
|negative regulation of cellular response to growth factor stimulus|
|cellular response to interleukin-1|
|regulation of morphogenesis of an epithelium|
|cell-substrate adhesion|
|carbohydrate derivative catabolic process|
|response to interleukin-1|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|regulation of cellular response to growth factor stimulus|
|regulation of inflammatory response|
|glycoprotein metabolic process|
|cellular response to growth factor stimulus|
|response to growth factor|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|negative regulation of cell differentiation|
|regulation of defense response|
|cellular macromolecule catabolic process|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|proteolysis|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15368
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAMTS12 Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>