ADAMTS12

Gene Information

Official Symbol: ADAMTS12
Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Aliases and Previous Symbols: N/A
Entrez ID: 81792
UniProt: P58397
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15368
Expression level (log2 read counts): -3.9

Expression Distribution

Pep M12B propep
ADAM spacer1
TSP 1
Reprolysin

negative regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of cellular response to hepatocyte growth factor stimulus
regulation of cellular response to hepatocyte growth factor stimulus
proteoglycan catabolic process
regulation of hepatocyte growth factor receptor signaling pathway
regulation of endothelial tube morphogenesis
negative regulation of cellular response to vascular endothelial growth factor stimulus
regulation of cellular response to vascular endothelial growth factor stimulus
glycoprotein catabolic process
negative regulation of chondrocyte differentiation
negative regulation of cartilage development
regulation of chondrocyte differentiation
regulation of cartilage development
proteoglycan metabolic process
metalloendopeptidase activity
cellular response to BMP stimulus
response to BMP
cell-matrix adhesion
negative regulation of cellular response to growth factor stimulus
cellular response to interleukin-1
regulation of morphogenesis of an epithelium
cell-substrate adhesion
carbohydrate derivative catabolic process
response to interleukin-1
cellular response to tumor necrosis factor
response to tumor necrosis factor
regulation of cellular response to growth factor stimulus
regulation of inflammatory response
glycoprotein metabolic process
cellular response to growth factor stimulus
response to growth factor
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
negative regulation of cell differentiation
regulation of defense response
cellular macromolecule catabolic process
cell adhesion
biological adhesion
negative regulation of developmental process