ADAMTS13

• Official Symbol: ADAMTS13
• Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
• Aliases and Previous Symbols: N/A
• Entrez ID: 11093
• UniProt: Q76LX8
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
• UniProt Summary: Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. {ECO:0000269|PubMed:19880749}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 5747
• Expression level (log2 read counts): -0.78

Expression Distribution

×

ADAMTS13 Expression in NALM6 Cells: -0.78