ADAMTS20

Entrez Summary: The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011].
UniProt Summary: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of melanocyte differentiation
regulation of melanocyte differentiation
positive regulation of pigment cell differentiation
regulation of pigment cell differentiation
positive regulation of developmental pigmentation
regulation of developmental pigmentation
metalloendopeptidase activity
extracellular matrix organization
collagen-containing extracellular matrix
extracellular structure organization
zinc ion binding
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell differentiation
negative regulation of cell death
proteolysis
positive regulation of developmental process
regulation of apoptotic process
regulation of programmed cell death
extracellular space
positive regulation of signal transduction
regulation of cell death
regulation of cell differentiation
positive regulation of cell communication
positive regulation of signaling