ADAMTS9

Entrez Summary: N/A
UniProt Summary: Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428- Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. {ECO:0000269|PubMed:12514189, ECO:0000269|PubMed:22419820}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Metformin 40μM R03 exp132	-1.73
UM131593 0.1μM R01 exp58	1.84

endothelial cell-matrix adhesion
positive regulation of melanocyte differentiation
regulation of melanocyte differentiation
positive regulation of pigment cell differentiation
regulation of pigment cell differentiation
positive regulation of developmental pigmentation
regulation of developmental pigmentation
glycoprotein catabolic process
negative regulation of sprouting angiogenesis
aorta morphogenesis
negative regulation of endothelial cell migration
aorta development
heart valve morphogenesis
ventricular cardiac muscle tissue development
artery morphogenesis
heart valve development
metallopeptidase activity
negative regulation of epithelial cell migration
regulation of sprouting angiogenesis
artery development
negative regulation of angiogenesis
metalloendopeptidase activity
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
cell-matrix adhesion
regulation of endothelial cell migration
cardiac muscle tissue development
cell-substrate adhesion
carbohydrate derivative catabolic process
regulation of epithelial cell migration
extracellular matrix
negative regulation of cell migration
negative regulation of cell motility
striated muscle tissue development
regulation of angiogenesis
muscle tissue development
negative regulation of cellular component movement
regulation of vasculature development
negative regulation of locomotion
extracellular matrix organization