ADAR [The Human Chemical-Genetic Interaction Map Project]

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======= ADAR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAR
  * **<color #00a2e8>Official Name</color>**: adenosine deaminase RNA specific
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=103|103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55265|P55265]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsrm|
|A deamin|
|z-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of RNA interference|
|supraspliceosomal complex|
|regulation of RNA interference|
|hematopoietic stem cell homeostasis|
|double-stranded RNA adenosine deaminase activity|
|tRNA-specific adenosine deaminase activity|
|miRNA loading onto RISC involved in gene silencing by miRNA|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|adenosine to inosine editing|
|small RNA loading onto RISC|
|pre-miRNA processing|
|negative regulation of type I interferon-mediated signaling pathway|
|negative regulation of posttranscriptional gene silencing|
|negative regulation of gene silencing by RNA|
|definitive hemopoiesis|
|somatic diversification of immune receptors via somatic mutation|
|base conversion or substitution editing|
|response to interferon-alpha|
|production of miRNAs involved in gene silencing by miRNA|
|cellular response to virus|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|regulation of type I interferon-mediated signaling pathway|
|positive regulation of viral genome replication|
|negative regulation of gene silencing|
|gene silencing by miRNA|
|somatic diversification of immune receptors|
|negative regulation of innate immune response|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of viral life cycle|
|negative regulation of response to cytokine stimulus|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|double-stranded RNA binding|
|response to type I interferon|
|erythrocyte differentiation|
|hematopoietic progenitor cell differentiation|
|gene silencing by RNA|
|erythrocyte homeostasis|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|negative regulation of response to biotic stimulus|
|regulation of viral genome replication|
|myeloid cell homeostasis|
|positive regulation of viral process|
|osteoblast differentiation|
|regulation of gene silencing|
|regulation of viral life cycle|
|negative regulation of immune response|
|gene silencing|
|regulation of cytokine-mediated signaling pathway|
|RNA modification|
|regulation of response to cytokine stimulus|
|defense response to virus|
|homeostasis of number of cells|
|regulation of viral process|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of protein kinase activity|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|negative regulation of kinase activity|
|ossification|
|negative regulation of transferase activity|
|response to virus|
|negative regulation of response to external stimulus|
|ncRNA processing|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|immune system development|
|cytokine-mediated signaling pathway|
|mRNA metabolic process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|defense response to other organism|
|regulation of transferase activity|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-2.14|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.84|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.84|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.8|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.8|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.74|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.88|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.92|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 26/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAR Expression in NALM6 Cells: 8.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>