ADAR
Gene Information
- Official Symbol: ADAR
- Official Name: adenosine deaminase RNA specific
- Aliases and Previous Symbols: N/A
- Entrez ID: 103
- UniProt: P55265
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| dsrm |
| A deamin |
| z-alpha |
GO Terms
| negative regulation of RNA interference |
| supraspliceosomal complex |
| regulation of RNA interference |
| hematopoietic stem cell homeostasis |
| double-stranded RNA adenosine deaminase activity |
| tRNA-specific adenosine deaminase activity |
| miRNA loading onto RISC involved in gene silencing by miRNA |
| negative regulation of protein kinase activity by regulation of protein phosphorylation |
| adenosine to inosine editing |
| small RNA loading onto RISC |
| pre-miRNA processing |
| negative regulation of type I interferon-mediated signaling pathway |
| negative regulation of posttranscriptional gene silencing |
| negative regulation of gene silencing by RNA |
| definitive hemopoiesis |
| somatic diversification of immune receptors via somatic mutation |
| base conversion or substitution editing |
| response to interferon-alpha |
| production of miRNAs involved in gene silencing by miRNA |
| cellular response to virus |
| dsRNA processing |
| production of small RNA involved in gene silencing by RNA |
| regulation of type I interferon-mediated signaling pathway |
| positive regulation of viral genome replication |
| negative regulation of gene silencing |
| gene silencing by miRNA |
| somatic diversification of immune receptors |
| negative regulation of innate immune response |
| posttranscriptional gene silencing by RNA |
| posttranscriptional gene silencing |
| negative regulation of cytokine-mediated signaling pathway |
| positive regulation of viral life cycle |
| negative regulation of response to cytokine stimulus |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| double-stranded RNA binding |
| response to type I interferon |
| erythrocyte differentiation |
| hematopoietic progenitor cell differentiation |
| gene silencing by RNA |
| erythrocyte homeostasis |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| negative regulation of response to biotic stimulus |
| regulation of viral genome replication |
| myeloid cell homeostasis |
| positive regulation of viral process |
| osteoblast differentiation |
| regulation of gene silencing |
| regulation of viral life cycle |
| negative regulation of immune response |
| gene silencing |
| regulation of cytokine-mediated signaling pathway |
| RNA modification |
| regulation of response to cytokine stimulus |
| defense response to virus |
| homeostasis of number of cells |
| regulation of viral process |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| myeloid cell differentiation |
| regulation of symbiosis, encompassing mutualism through parasitism |
| negative regulation of protein kinase activity |
| ribonucleoprotein complex assembly |
| regulation of gene expression, epigenetic |
| ribonucleoprotein complex subunit organization |
| negative regulation of kinase activity |
| ossification |
| negative regulation of transferase activity |
| response to virus |
| negative regulation of response to external stimulus |
| ncRNA processing |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of innate immune response |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| mRNA processing |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| hematopoietic or lymphoid organ development |
| immune system development |
| cytokine-mediated signaling pathway |
| mRNA metabolic process |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| cellular protein-containing complex assembly |
| nucleolus |
| regulation of kinase activity |
| RNA processing |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| defense response to other organism |
| regulation of transferase activity |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| negative regulation of cellular protein metabolic process |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| RNA binding |
| regulation of protein phosphorylation |
| DNA binding |
| regulation of response to stress |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| immune response |
| positive regulation of gene expression |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| B02 10μM R08 exp453 | -2.14 |
| AICAR 240μM R05 exp211 | -1.84 |
| Doxorubicin 0.02μM R08 exp478 | -1.84 |
| Citral 50μM R06 exp274 | -1.8 |
| Dynasore 7μM R08 exp436 | -1.8 |
| Rapamycin 1μM R00 exp29 | 1.74 |
| Wortmannin 5μM R00 exp38 | 1.88 |
| MK2206 4μM R08 exp504 | 1.92 |
| Heregulin-B 44ng/ml R08 exp486 | 2.28 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 26/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 2/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 3/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 1/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1674
- Expression level (log2 read counts): 8.96
Expression Distribution
ADAR Expression in NALM6 Cells: 8.96
