ADC [The Human Chemical-Genetic Interaction Map Project]

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======= ADC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AZIN2
  * **<color #00a2e8>Official Name</color>**: antizyme inhibitor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=113451|113451]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A70|Q96A70]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Orn DAP Arg deC|
|Orn Arg deC N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arginine decarboxylase activity|
|granular vesicle|
|trans-Golgi network membrane organization|
|positive regulation of polyamine transmembrane transport|
|agmatine biosynthetic process|
|putrescine transmembrane transporter activity|
|putrescine transport|
|ornithine decarboxylase activator activity|
|putrescine biosynthetic process from ornithine|
|ornithine decarboxylase activity|
|polyamine transport|
|putrescine biosynthetic process|
|regulation of polyamine transmembrane transport|
|primary amino compound biosynthetic process|
|putrescine metabolic process|
|ornithine metabolic process|
|polyamine biosynthetic process|
|primary amino compound metabolic process|
|polyamine metabolic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|organic cation transport|
|ammonium transport|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|cis-Golgi network|
|amine metabolic process|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|transport vesicle|
|negative regulation of protein catabolic process|
|perikaryon|
|trans-Golgi network|
|ammonium ion metabolic process|
|positive regulation of transmembrane transport|
|alpha-amino acid metabolic process|
|cytoplasmic vesicle|
|axon|
|cellular amino acid metabolic process|
|negative regulation of catabolic process|
|regulation of protein catabolic process|
|dendrite|
|spermatogenesis|
|regulation of transmembrane transport|
|male gamete generation|
|gamete generation|
|perinuclear region of cytoplasm|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|carboxylic acid metabolic process|
|positive regulation of transport|
|regulation of catabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of protein metabolic process|
|mitochondrion|
|ion transport|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10980
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADC Expression in NALM6 Cells: -1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>