ADC
Gene Information
- Official Symbol: AZIN2
- Official Name: antizyme inhibitor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 113451
- UniProt: Q96A70
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Orn DAP Arg deC |
| Orn Arg deC N |
GO Terms
| arginine decarboxylase activity |
| granular vesicle |
| trans-Golgi network membrane organization |
| positive regulation of polyamine transmembrane transport |
| agmatine biosynthetic process |
| putrescine transmembrane transporter activity |
| putrescine transport |
| ornithine decarboxylase activator activity |
| putrescine biosynthetic process from ornithine |
| ornithine decarboxylase activity |
| polyamine transport |
| putrescine biosynthetic process |
| regulation of polyamine transmembrane transport |
| primary amino compound biosynthetic process |
| putrescine metabolic process |
| ornithine metabolic process |
| polyamine biosynthetic process |
| primary amino compound metabolic process |
| polyamine metabolic process |
| cellular biogenic amine biosynthetic process |
| amine biosynthetic process |
| organic cation transport |
| ammonium transport |
| cellular biogenic amine metabolic process |
| cellular amine metabolic process |
| cis-Golgi network |
| amine metabolic process |
| endoplasmic reticulum-Golgi intermediate compartment membrane |
| transport vesicle |
| negative regulation of protein catabolic process |
| perikaryon |
| trans-Golgi network |
| ammonium ion metabolic process |
| positive regulation of transmembrane transport |
| alpha-amino acid metabolic process |
| cytoplasmic vesicle |
| axon |
| cellular amino acid metabolic process |
| negative regulation of catabolic process |
| regulation of protein catabolic process |
| dendrite |
| spermatogenesis |
| regulation of transmembrane transport |
| male gamete generation |
| gamete generation |
| perinuclear region of cytoplasm |
| multicellular organismal reproductive process |
| cation transport |
| sexual reproduction |
| multicellular organism reproduction |
| membrane organization |
| carboxylic acid metabolic process |
| positive regulation of transport |
| regulation of catabolic process |
| multi-organism reproductive process |
| oxoacid metabolic process |
| organic acid metabolic process |
| negative regulation of protein metabolic process |
| mitochondrion |
| ion transport |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| positive regulation of molecular function |
| nitrogen compound transport |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trimetrexate 0.03μM R08 exp535 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10980
- Expression level (log2 read counts): -1.52
Expression Distribution
ADC Expression in NALM6 Cells: -1.52
