ADCK4

Entrez Summary: This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420). {ECO:0000250|UniProtKB:Q8NI60, ECO:0000269|PubMed:24270420}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellar Purkinje cell layer morphogenesis
extrinsic component of mitochondrial inner membrane
quinone biosynthetic process
ubiquinone biosynthetic process
ubiquinone metabolic process
cerebellar Purkinje cell layer development
ketone biosynthetic process
cerebellar cortex morphogenesis
quinone metabolic process
cerebellum morphogenesis
hindbrain morphogenesis
cerebellar cortex development
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
kinase activity
cerebellum development
metencephalon development
coenzyme biosynthetic process
hindbrain development
cofactor biosynthetic process
protein kinase activity
coenzyme metabolic process
cofactor metabolic process
small molecule biosynthetic process
brain development
head development
protein phosphorylation
central nervous system development
mitochondrion
phosphorylation
ATP binding
small molecule metabolic process