ADCY2 [The Human Chemical-Genetic Interaction Map Project]

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======= ADCY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCY2
  * **<color #00a2e8>Official Name</color>**: adenylate cyclase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=108|108]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08462|Q08462]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103071|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1053|
|Guanylate cyc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase activity|
|cAMP biosynthetic process|
|cellular response to forskolin|
|response to forskolin|
|response to platelet aggregation inhibitor|
|adenylate cyclase binding|
|activation of protein kinase A activity|
|cAMP metabolic process|
|cyclic nucleotide biosynthetic process|
|cyclic purine nucleotide metabolic process|
|cellular response to glucagon stimulus|
|renal water homeostasis|
|response to glucagon|
|activation of adenylate cyclase activity|
|cyclic nucleotide metabolic process|
|manganese ion binding|
|multicellular organismal water homeostasis|
|water homeostasis|
|cellular response to alcohol|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to ketone|
|renal system process|
|cellular response to antibiotic|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|response to ketone|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|magnesium ion binding|
|membrane raft|
|response to alcohol|
|nucleotide biosynthetic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|nucleoside phosphate biosynthetic process|
|cellular response to peptide hormone stimulus|
|response to antibiotic|
|purine ribonucleotide metabolic process|
|multicellular organismal homeostasis|
|ribonucleotide metabolic process|
|cellular response to peptide|
|activation of protein kinase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|response to peptide hormone|
|cellular response to drug|
|dendrite|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|protein heterodimerization activity|
|regulation of body fluid levels|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of protein kinase activity|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|response to hormone|
|response to organic cyclic compound|
|regulation of transferase activity|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCY2 Expression in NALM6 Cells: 3.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>