ADCY2

Entrez Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF1053
Guanylate cyc

adenylate cyclase activity
cAMP biosynthetic process
cellular response to forskolin
response to forskolin
response to platelet aggregation inhibitor
adenylate cyclase binding
activation of protein kinase A activity
cAMP metabolic process
cyclic nucleotide biosynthetic process
cyclic purine nucleotide metabolic process
cellular response to glucagon stimulus
renal water homeostasis
response to glucagon
activation of adenylate cyclase activity
cyclic nucleotide metabolic process
manganese ion binding
multicellular organismal water homeostasis
water homeostasis
cellular response to alcohol
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to ketone
renal system process
cellular response to antibiotic
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
cyclic-nucleotide-mediated signaling
response to ketone
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
magnesium ion binding
membrane raft
response to alcohol
nucleotide biosynthetic process
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
nucleoside phosphate biosynthetic process
cellular response to peptide hormone stimulus