ADCYAP1
Gene Information
- Official Symbol: ADCYAP1
- Official Name: adenylate cyclase activating polypeptide 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 116
- UniProt: P18509
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:O70176, ECO:0000250|UniProtKB:P13589, ECO:0000269|PubMed:11175907, ECO:0000269|PubMed:23800469}.
Pfam Domains GO Terms
Pfam Domains
| Hormone 2 |
GO Terms
| negative regulation of acute inflammatory response to non-antigenic stimulus |
| pituitary adenylate cyclase activating polypeptide activity |
| pituitary adenylate cyclase-activating polypeptide receptor binding |
| regulation of somatostatin secretion |
| positive regulation of somatostatin secretion |
| regulation of acute inflammatory response to non-antigenic stimulus |
| positive regulation of chemokine (C-C motif) ligand 5 production |
| negative regulation of acute inflammatory response to antigenic stimulus |
| histamine secretion |
| histamine transport |
| regulation of oligodendrocyte progenitor proliferation |
| positive regulation of growth hormone secretion |
| regulation of chemokine (C-C motif) ligand 5 production |
| peptide hormone receptor binding |
| negative regulation of acute inflammatory response |
| negative regulation of inflammatory response to antigenic stimulus |
| regulation of acute inflammatory response to antigenic stimulus |
| regulation of growth hormone secretion |
| negative regulation of glial cell proliferation |
| azole transport |
| positive regulation of cAMP-mediated signaling |
| regulation of inflammatory response to antigenic stimulus |
| neuropeptide hormone activity |
| behavioral fear response |
| regulation of glial cell proliferation |
| behavioral defense response |
| positive regulation of synaptic transmission, glutamatergic |
| negative regulation of potassium ion transport |
| fear response |
| negative regulation of muscle cell apoptotic process |
| insulin secretion |
| activation of adenylate cyclase activity |
| negative regulation of gliogenesis |
| pituitary gland development |
| regulation of acute inflammatory response |
| negative regulation of GTPase activity |
| regulation of cAMP-mediated signaling |
| terminal bouton |
| ovarian follicle development |
| ammonium transport |
| cellular response to glucocorticoid stimulus |
| positive regulation of chemokine production |
| positive regulation of blood vessel diameter |
| peptide hormone secretion |
| cellular response to corticosteroid stimulus |
| regulation of muscle cell apoptotic process |
| multicellular organismal response to stress |
| regulation of synaptic transmission, glutamatergic |
| hormone secretion |
| sensory perception of pain |
| diencephalon development |
| regulation of chemokine production |
| hormone transport |
| regulation of neural precursor cell proliferation |
| female gonad development |
| development of primary female sexual characteristics |
| positive regulation of interleukin-6 production |
| regulation of potassium ion transport |
| positive regulation of peptide hormone secretion |
| positive regulation of cold-induced thermogenesis |
| regulation of postsynaptic membrane potential |
| neuropeptide signaling pathway |
| female sex differentiation |
| regulation of gliogenesis |
| endocrine system development |
| response to ethanol |
| positive regulation of hormone secretion |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| perikaryon |
| negative regulation of inflammatory response |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of interleukin-6 production |
| regulation of tube size |
| regulation of G protein-coupled receptor signaling pathway |
| regulation of cold-induced thermogenesis |
| response to glucocorticoid |
| negative regulation of ion transport |
| cAMP-mediated signaling |
| negative regulation of immune response |
| positive regulation of synaptic transmission |
| protein secretion |
| establishment of protein localization to extracellular region |
| response to corticosteroid |
| protein localization to extracellular region |
| signal release |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| peptide secretion |
| neurotransmitter transport |
| female pregnancy |
| cellular response to steroid hormone stimulus |
| response to starvation |
| ATP metabolic process |
| negative regulation of defense response |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| gonad development |
| regulation of peptide hormone secretion |
| positive regulation of ERK1 and ERK2 cascade |
| multi-multicellular organism process |
| development of primary sexual characteristics |
| response to alcohol |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| sex differentiation |
| regulation of hormone secretion |
| positive regulation of neuron projection development |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| negative regulation of neurogenesis |
| regulation of ERK1 and ERK2 cascade |
| response to antibiotic |
| negative regulation of nervous system development |
| neuron projection |
| response to steroid hormone |
| regulation of cytosolic calcium ion concentration |
| negative regulation of cell development |
| signaling receptor binding |
| regulation of inflammatory response |
| second-messenger-mediated signaling |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| forebrain development |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| gland development |
| positive regulation of GTPase activity |
| reproductive structure development |
| reproductive system development |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| regulation of GTPase activity |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| response to nutrient levels |
| response to toxic substance |
| regulation of anatomical structure size |
| cellular response to lipid |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| regulation of hormone levels |
| positive regulation of nervous system development |
| cellular response to organic cyclic compound |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| cellular metal ion homeostasis |
| behavior |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| cellular response to hormone stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| cation homeostasis |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| regulation of peptide transport |
| brain development |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| positive regulation of hydrolase activity |
| head development |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| cation transport |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| sensory perception |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| negative regulation of cell death |
| multi-organism reproductive process |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| defense response |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7120
- Expression level (log2 read counts): -3.13
Expression Distribution
ADCYAP1 Expression in NALM6 Cells: -3.13
