ADGRB1

Gene Information

Official Symbol: ADGRB1
Official Name: adhesion G protein-coupled receptor B1
Aliases and Previous Symbols: N/A
Entrez ID: 575
UniProt: O14514
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}. Vasculostatin-40: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5049
Expression level (log2 read counts): -2.38

Expression Distribution

Screen	Score
Hydroxychloroquine 30μM R08 exp490	1.71
Sucrose 20000μM R06 exp298	1.81

GPS
DUF3497
7tm 2
TSP 1

engulfment of apoptotic cell
positive regulation of myoblast fusion
regulation of myoblast fusion
phagocytic cup
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
positive regulation of myotube differentiation
lipopolysaccharide binding
apoptotic cell clearance
negative regulation of endothelial cell migration
positive regulation of reactive oxygen species biosynthetic process
regulation of myotube differentiation
positive regulation of striated muscle cell differentiation
phosphatidylserine binding
positive regulation of synapse assembly
negative regulation of epithelial cell migration
peripheral nervous system development
negative regulation of protein ubiquitination
negative regulation of protein modification by small protein conjugation or removal
defense response to Gram-negative bacterium
regulation of reactive oxygen species biosynthetic process
positive regulation of muscle cell differentiation
PDZ domain binding
positive regulation of reactive oxygen species metabolic process
regulation of striated muscle cell differentiation
negative regulation of angiogenesis
regulation of synapse assembly
negative regulation of blood vessel morphogenesis
phagocytosis, recognition
negative regulation of vasculature development
adenylate cyclase-activating G protein-coupled receptor signaling pathway
phagocytosis, engulfment
negative regulation of protein catabolic process
plasma membrane invagination
membrane invagination
cAMP-mediated signaling
dendritic spine
regulation of muscle cell differentiation
regulation of endothelial cell migration
cell-cell junction