ADH7

Entrez Summary: N/A
UniProt Summary: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.29
CyclicAMP 200μM R08 exp475	-1.96
BI-6727 0.0125μM R03 exp97	-1.94
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.92

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADH zinc N
ADH N

fatty acid omega-oxidation
aldehyde oxidase activity
ethanol binding
alcohol dehydrogenase (NAD) activity
alcohol dehydrogenase activity, zinc-dependent
ethanol oxidation
ethanol catabolic process
retinol binding
primary alcohol catabolic process
ethanol metabolic process
retinol dehydrogenase activity
receptor antagonist activity
retinoic acid metabolic process
retinol metabolic process
antibiotic catabolic process
alcohol catabolic process
negative regulation of signaling receptor activity
organic hydroxy compound catabolic process
primary alcohol metabolic process
fatty acid oxidation
lipid oxidation
retinoid metabolic process
antibiotic metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
response to ethanol
isoprenoid metabolic process
drug catabolic process
regulation of signaling receptor activity
lipid modification
hormone metabolic process
response to alcohol
response to antibiotic
alcohol metabolic process
fatty acid metabolic process
generation of precursor metabolites and energy
small molecule catabolic process
organic hydroxy compound metabolic process
drug metabolic process