ADHFE1

Entrez Summary: N/A
UniProt Summary: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. {ECO:0000269|PubMed:16435184}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutamate catabolic process via 2-oxoglutarate
hydroxyacid-oxoacid transhydrogenase activity
alcohol dehydrogenase (NAD) activity
glutamate catabolic process
2-oxoglutarate metabolic process
dicarboxylic acid catabolic process
glutamine family amino acid catabolic process
glutamate metabolic process
glutamine family amino acid metabolic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
mitochondrial matrix
small molecule catabolic process
cofactor metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process