ADI1

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255|HAMAP- Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:15938715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ARD
Cupin 2

acireductone dioxygenase [iron(II)-requiring] activity
L-methionine salvage from methylthioadenosine
L-methionine biosynthetic process
amino acid salvage
L-methionine salvage
methionine biosynthetic process
methionine metabolic process
sulfur amino acid biosynthetic process
aspartate family amino acid biosynthetic process
cellular metabolic compound salvage
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
oxidoreductase activity
iron ion binding
sulfur compound biosynthetic process
alpha-amino acid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
sulfur compound metabolic process
drug metabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process