ADIPOR2 [The Human Chemical-Genetic Interaction Map Project]

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======= ADIPOR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADIPOR2
  * **<color #00a2e8>Official Name</color>**: adiponectin receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79602|79602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86V24|Q86V24]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADIPOR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADIPOR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). {ECO:0000250|UniProtKB:Q8BQS5, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HlyIII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adipokinetic hormone receptor activity|
|adiponectin binding|
|vascular wound healing|
|adiponectin-activated signaling pathway|
|angiogenesis involved in wound healing|
|positive regulation of glucose import|
|intrinsic component of plasma membrane|
|positive regulation of glucose transmembrane transport|
|regulation of fatty acid biosynthetic process|
|regulation of glucose import|
|regulation of glucose transmembrane transport|
|fatty acid oxidation|
|lipid oxidation|
|regulation of fatty acid metabolic process|
|positive regulation of cold-induced thermogenesis|
|regulation of cold-induced thermogenesis|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|female pregnancy|
|negative regulation of cell growth|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|lipid modification|
|positive regulation of transmembrane transport|
|signaling receptor activity|
|multi-multicellular organism process|
|response to nutrient|
|negative regulation of growth|
|angiogenesis|
|fatty acid metabolic process|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|wound healing|
|blood vessel development|
|protein heterodimerization activity|
|response to nutrient levels|
|vasculature development|
|cardiovascular system development|
|heart development|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of transmembrane transport|
|response to wounding|
|cellular response to hormone stimulus|
|tube morphogenesis|
|regulation of growth|
|cytokine-mediated signaling pathway|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|response to hormone|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of transport|
|multi-organism reproductive process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|identical protein binding|
|response to cytokine|
|chemical homeostasis|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-3.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-3.3|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.81|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.76|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.54|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.46|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.35|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.33|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.28|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.25|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.25|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.22|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.15|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.03|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.01|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.99|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.99|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.98|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.95|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.89|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.82|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.8|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.78|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.78|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.76|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.76|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.73|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.73|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.89|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9633
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADIPOR2 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>