ADIPOR2

Entrez Summary: N/A
UniProt Summary: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). {ECO:0000250|UniProtKB:Q8BQS5, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pterostilbene 16μM R02 exp78	-3.78
Temozolomide 200μM R04 exp189	-3.3
Pimelic-diphenylamide-106 5μM R00 exp28	-2.81
Resveratrol 16μM R03 exp147	-2.76
Actinomycin-D 0.01μM R00 exp4	-2.54
Hydroxychloroquine 30μM R08 exp490	-2.46
Curcumin 6.5μM R06 exp277	-2.35
Bisphenol F 50μM R08 exp457	-2.33
Dynasore 7μM R08 exp436	-2.28
MLN-4924 2μM R00 exp22	-2.25
UM0125461 0.74μM R02 exp84	-2.25
Etoposide 1μM R00 exp19	-2.22
WNT3A 44ng/ml R08 exp537	-2.15
UMK57 1μM R01 exp59	-2.03
NFN1 0.1μM R01 exp49	-2.01
Daidzin 10μM R06 exp280	-1.99
Docetaxel 0.002μM R01 exp45	-1.99
Nicotine 3000μM R08 exp510	-1.98
Chloroquine 32μM R08 exp470	-1.95
Vinorelbine 0.001μM R05 exp249	-1.89
Dynasore 10μM R04 exp180	-1.82
CyclicAMP 200μM R08 exp475	-1.8
BN82002 4μM R07 exp340	-1.78
THZ531 0.225μM R08 exp444	-1.78
Cincreasin 100μM R08 exp473	-1.76
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.76
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.75
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.73
Cycloheximide 0.2μM R00 exp15	-1.73
Ibrutinib 1μM R07 exp372	1.89
Vemurafenib 6.6μM R08 exp434	2.44

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adipokinetic hormone receptor activity
adiponectin binding
vascular wound healing
adiponectin-activated signaling pathway
angiogenesis involved in wound healing
positive regulation of glucose import
intrinsic component of plasma membrane
positive regulation of glucose transmembrane transport
regulation of fatty acid biosynthetic process
regulation of glucose import
regulation of glucose transmembrane transport
fatty acid oxidation
lipid oxidation
regulation of fatty acid metabolic process
positive regulation of cold-induced thermogenesis
regulation of cold-induced thermogenesis
hormone-mediated signaling pathway
regulation of cellular ketone metabolic process
female pregnancy
negative regulation of cell growth
glucose homeostasis
carbohydrate homeostasis
regulation of lipid biosynthetic process
lipid modification
positive regulation of transmembrane transport
signaling receptor activity
multi-multicellular organism process
response to nutrient
negative regulation of growth
angiogenesis
fatty acid metabolic process
regulation of lipid metabolic process
blood vessel morphogenesis
regulation of cell growth
regulation of small molecule metabolic process
wound healing
blood vessel development
protein heterodimerization activity
response to nutrient levels
vasculature development