ADM2

Entrez Summary: N/A
UniProt Summary: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. {ECO:0000269|PubMed:14615490}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of blood pressure
feeding behavior
hormone activity
digestion
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
positive regulation of angiogenesis
cyclic-nucleotide-mediated signaling
regulation of blood pressure
positive regulation of vasculature development
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
protein-containing complex binding
regulation of angiogenesis
angiogenesis
regulation of vasculature development
second-messenger-mediated signaling
blood circulation
circulatory system process
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
behavior
tube morphogenesis
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
protein phosphorylation
regulation of anatomical structure morphogenesis
phosphorylation
G protein-coupled receptor signaling pathway
positive regulation of developmental process
intracellular signal transduction
positive regulation of multicellular organismal process
extracellular region
system process
positive regulation of gene expression