ADORA2B
Gene Information
- Official Symbol: ADORA2B
- Official Name: adenosine A2b receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 136
- UniProt: P29275
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srsx |
GO Terms
| regulation of chronic inflammatory response to non-antigenic stimulus |
| positive regulation of chronic inflammatory response to non-antigenic stimulus |
| positive regulation of chronic inflammatory response |
| G protein-coupled adenosine receptor activity |
| relaxation of vascular smooth muscle |
| positive regulation of cGMP-mediated signaling |
| relaxation of smooth muscle |
| adenosine receptor signaling pathway |
| regulation of chronic inflammatory response |
| positive regulation of guanylate cyclase activity |
| regulation of guanylate cyclase activity |
| negative regulation of smooth muscle contraction |
| regulation of cGMP-mediated signaling |
| positive regulation of mast cell degranulation |
| positive regulation of mast cell activation involved in immune response |
| G protein-coupled purinergic receptor signaling pathway |
| positive regulation of mast cell activation |
| relaxation of muscle |
| positive regulation of cyclase activity |
| positive regulation of purine nucleotide biosynthetic process |
| positive regulation of nucleotide biosynthetic process |
| negative regulation of muscle contraction |
| positive regulation of lyase activity |
| positive regulation of leukocyte degranulation |
| positive regulation of vascular endothelial growth factor production |
| purinergic receptor signaling pathway |
| vasodilation |
| positive regulation of myeloid leukocyte mediated immunity |
| regulation of vascular endothelial growth factor production |
| regulation of mast cell degranulation |
| regulation of mast cell activation involved in immune response |
| activation of adenylate cyclase activity |
| regulation of purine nucleotide biosynthetic process |
| regulation of nucleotide biosynthetic process |
| excretion |
| regulation of cyclase activity |
| positive regulation of purine nucleotide metabolic process |
| regulation of lyase activity |
| regulation of mast cell activation |
| positive regulation of nucleotide metabolic process |
| regulation of leukocyte degranulation |
| positive regulation of regulated secretory pathway |
| cellular defense response |
| positive regulation of chemokine production |
| positive regulation of blood vessel diameter |
| regulation of myeloid leukocyte mediated immunity |
| regulation of smooth muscle contraction |
| regulation of chemokine production |
| regulation of synaptic vesicle exocytosis |
| JNK cascade |
| Schaffer collateral - CA1 synapse |
| positive regulation of exocytosis |
| positive regulation of interleukin-6 production |
| stress-activated MAPK cascade |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| positive regulation of leukocyte mediated immunity |
| positive regulation of small molecule metabolic process |
| positive regulation of inflammatory response |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| regulation of interleukin-6 production |
| stress-activated protein kinase signaling cascade |
| regulation of neurotransmitter transport |
| cAMP-mediated signaling |
| activation of MAPK activity |
| regulation of muscle contraction |
| regulation of regulated secretory pathway |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| regulation of leukocyte mediated immunity |
| positive regulation of intracellular transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of immune effector process |
| regulation of exocytosis |
| regulation of muscle system process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of MAP kinase activity |
| cellular response to extracellular stimulus |
| muscle system process |
| activation of protein kinase activity |
| cellular response to external stimulus |
| second-messenger-mediated signaling |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| glutamatergic synapse |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| MAPK cascade |
| blood circulation |
| signal transduction by protein phosphorylation |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of small molecule metabolic process |
| positive regulation of secretion |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of cytokine production |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| positive regulation of kinase activity |
| regulation of system process |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| regulation of cell activation |
| positive regulation of transferase activity |
| regulation of cytokine production |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of protein kinase activity |
| regulation of secretion |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of cellular localization |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| phosphorylation |
| G protein-coupled receptor signaling pathway |
| defense response |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 19015
- Expression level (log2 read counts): 1.64
Expression Distribution
ADORA2B Expression in NALM6 Cells: 1.64
