ADORA3
Gene Information
- Official Symbol: ADORA3
- Official Name: adenosine A3 receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 140
- UniProt: P0DMS8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].
- UniProt Summary: Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299). {ECO:0000269|PubMed:8234299}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9055
- Expression level (log2 read counts): -1.82
ADORA3 Expression in NALM6 Cells: -1.82
