ADPGK

Entrez Summary: N/A
UniProt Summary: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADP-specific glucokinase activity
glucose catabolic process to pyruvate
NADH regeneration
canonical glycolysis
glycolytic process through glucose-6-phosphate
glycolytic process through fructose-6-phosphate
glucose catabolic process
NADH metabolic process
glycolytic process
ATP generation from ADP
NAD metabolic process
ADP metabolic process
hexose catabolic process
nucleoside diphosphate phosphorylation
monosaccharide catabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
nucleoside diphosphate metabolic process
glucose metabolic process
carbohydrate catabolic process
hexose metabolic process
monosaccharide metabolic process
ATP metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
generation of precursor metabolites and energy
small molecule catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
organophosphate metabolic process
carboxylic acid metabolic process