ADRA2B

Gene Information

Official Symbol: ADRA2B
Official Name: adrenoceptor alpha 2B
Aliases and Previous Symbols: N/A
Entrez ID: 151
UniProt: P18089
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014].
UniProt Summary: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. {ECO:0000269|PubMed:23105096}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3884
Expression level (log2 read counts): -3.21

Expression Distribution

7tm 1
7TM GPCR Srsx
7TM GPCR Srx

alpha2-adrenergic receptor activity
receptor transactivation
negative regulation of epinephrine secretion
positive regulation of uterine smooth muscle contraction
regulation of vascular smooth muscle contraction
epinephrine binding
regulation of epinephrine secretion
negative regulation of norepinephrine secretion
regulation of uterine smooth muscle contraction
negative regulation of catecholamine secretion
regulation of norepinephrine secretion
adrenergic receptor activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor signaling pathway
negative regulation of amine transport
positive regulation of smooth muscle contraction
activation of protein kinase B activity
positive regulation of signaling receptor activity
positive regulation of blood pressure
positive regulation of muscle contraction
regulation of vasoconstriction
regulation of smooth muscle contraction
regulation of catecholamine secretion
regulation of amine transport
adenylate cyclase-activating G protein-coupled receptor signaling pathway
platelet activation
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
cAMP-mediated signaling
activation of MAPK activity
regulation of muscle contraction
vascular process in circulatory system
cyclic-nucleotide-mediated signaling
regulation of signaling receptor activity
female pregnancy
regulation of blood pressure
negative regulation of secretion by cell
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
multi-multicellular organism process