ADRB1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ADRB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRB1
  * **<color #00a2e8>Official Name</color>**: adrenoceptor beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=153|153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08588|P08588]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269|PubMed:12391161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srx|
|7TM GPCR Srsx|
|7TM GPCR Srv|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta1-adrenergic receptor activity|
|beta-adrenergic receptor activity|
|positive regulation of the force of heart contraction by epinephrine-norepinephrine|
|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|
|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|
|positive regulation of the force of heart contraction by chemical signal|
|positive regulation of heart rate by epinephrine-norepinephrine|
|heat generation|
|alpha-2A adrenergic receptor binding|
|norepinephrine binding|
|positive regulation of blood pressure by epinephrine-norepinephrine|
|regulation of the force of heart contraction by chemical signal|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|epinephrine binding|
|negative regulation of multicellular organism growth|
|diet induced thermogenesis|
|Ras guanyl-nucleotide exchange factor activity|
|adrenergic receptor activity|
|negative regulation of systemic arterial blood pressure|
|adaptive thermogenesis|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|positive regulation of heart rate|
|response to dietary excess|
|regulation of the force of heart contraction|
|brown fat cell differentiation|
|vasodilation|
|temperature homeostasis|
|fear response|
|positive regulation of blood pressure|
|positive regulation of heart contraction|
|activation of adenylate cyclase activity|
|negative regulation of blood pressure|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|response to cold|
|positive regulation of blood vessel diameter|
|regulation of multicellular organism growth|
|multicellular organismal response to stress|
|positive regulation of blood circulation|
|Schaffer collateral - CA1 synapse|
|PDZ domain binding|
|regulation of systemic arterial blood pressure|
|regulation of heart rate|
|positive regulation of cold-induced thermogenesis|
|regulation of postsynaptic membrane potential|
|negative regulation of developmental growth|
|fat cell differentiation|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of cold-induced thermogenesis|
|cAMP-mediated signaling|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|response to temperature stimulus|
|regulation of blood pressure|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of heart contraction|
|negative regulation of growth|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|early endosome|
|regulation of blood circulation|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|positive regulation of GTPase activity|
|regulation of membrane potential|
|regulation of GTPase activity|
|protein heterodimerization activity|
|response to nutrient levels|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|regulation of system process|
|regulation of growth|
|positive regulation of hydrolase activity|
|negative regulation of developmental process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.71|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.71|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.71|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.612|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRB1 Expression in NALM6 Cells: 1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>