ADRB1

Gene Information

Official Symbol: ADRB1
Official Name: adrenoceptor beta 1
Aliases and Previous Symbols: N/A
Entrez ID: 153
UniProt: P08588
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008].
UniProt Summary: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269|PubMed:12391161}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4327
Expression level (log2 read counts): 1.27

Expression Distribution

Screen	Score
Nocodazole 0.2μM R02 exp64	-1.71
SB202190 10μM R03 exp148	1.71
Tubastatin-A 2.5μM R07 exp417	1.71
UM0131023 0.05μM R05 exp248	1.71

7TM GPCR Srx
7TM GPCR Srsx
7TM GPCR Srv
7tm 1

beta1-adrenergic receptor activity
beta-adrenergic receptor activity
positive regulation of the force of heart contraction by epinephrine-norepinephrine
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
positive regulation of the force of heart contraction by chemical signal
positive regulation of heart rate by epinephrine-norepinephrine
heat generation
alpha-2A adrenergic receptor binding
norepinephrine binding
positive regulation of blood pressure by epinephrine-norepinephrine
regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by norepinephrine-epinephrine
epinephrine binding
negative regulation of multicellular organism growth
diet induced thermogenesis
Ras guanyl-nucleotide exchange factor activity
adrenergic receptor activity
negative regulation of systemic arterial blood pressure
adaptive thermogenesis
adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of heart rate
response to dietary excess
regulation of the force of heart contraction
brown fat cell differentiation
vasodilation
temperature homeostasis
fear response
positive regulation of blood pressure
positive regulation of heart contraction
activation of adenylate cyclase activity
negative regulation of blood pressure
regulation of systemic arterial blood pressure mediated by a chemical signal
response to cold
positive regulation of blood vessel diameter
regulation of multicellular organism growth
multicellular organismal response to stress
positive regulation of blood circulation
Schaffer collateral - CA1 synapse