ADRB2 [The Human Chemical-Genetic Interaction Map Project]

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======= ADRB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRB2
  * **<color #00a2e8>Official Name</color>**: adrenoceptor beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=154|154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07550|P07550]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srx|
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta2-adrenergic receptor activity|
|positive regulation of mini excitatory postsynaptic potential|
|regulation of mini excitatory postsynaptic potential|
|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|
|desensitization of G protein-coupled receptor signaling pathway by arrestin|
|response to psychosocial stress|
|regulation of lipophagy|
|positive regulation of cAMP-dependent protein kinase activity|
|heat generation|
|positive regulation of lipophagy|
|norepinephrine binding|
|positive regulation of autophagosome maturation|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|epinephrine binding|
|positive regulation of AMPA receptor activity|
|positive regulation of protein kinase A signaling|
|negative regulation of multicellular organism growth|
|regulation of autophagosome maturation|
|diet induced thermogenesis|
|activation of transmembrane receptor protein tyrosine kinase activity|
|adenylate cyclase binding|
|negative regulation of smooth muscle contraction|
|regulation of cAMP-dependent protein kinase activity|
|positive regulation of glutamate receptor signaling pathway|
|adrenergic receptor activity|
|negative regulation of systemic arterial blood pressure|
|adaptive thermogenesis|
|negative adaptation of signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|regulation of protein kinase A signaling|
|adaptation of signaling pathway|
|negative regulation of muscle contraction|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|bone resorption|
|regulation of AMPA receptor activity|
|response to dietary excess|
|positive regulation of excitatory postsynaptic potential|
|brown fat cell differentiation|
|vasodilation|
|temperature homeostasis|
|positive regulation of signaling receptor activity|
|positive regulation of protein complex disassembly|
|activation of adenylate cyclase activity|
|positive regulation of bone mineralization|
|cellular response to amyloid-beta|
|modulation of excitatory postsynaptic potential|
|potassium channel regulator activity|
|negative regulation of blood pressure|
|bone remodeling|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|positive regulation of biomineralization|
|negative regulation of G protein-coupled receptor signaling pathway|
|positive regulation of biomineral tissue development|
|response to cold|
|response to amyloid-beta|
|endosome to lysosome transport|
|clathrin-coated vesicle membrane|
|positive regulation of blood vessel diameter|
|regulation of smooth muscle contraction|
|positive regulation of nervous system process|
|regulation of glutamate receptor signaling pathway|
|regulation of multicellular organism growth|
|positive regulation of macroautophagy|
|positive regulation of cation channel activity|
|regulation of bone mineralization|
|regulation of neurotransmitter receptor activity|
|amyloid-beta binding|
|positive regulation of ossification|
|regulation of sodium ion transport|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of systemic arterial blood pressure|
|positive regulation of cold-induced thermogenesis|
|tissue remodeling|
|negative regulation of protein binding|
|positive regulation of ion transmembrane transporter activity|
|negative regulation of developmental growth|
|fat cell differentiation|
|lysosomal transport|
|positive regulation of transporter activity|
|regulation of protein complex disassembly|
|positive regulation of protein ubiquitination|
|positive regulation of autophagy|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of nervous system process|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of cation transmembrane transport|
|vacuolar transport|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of cold-induced thermogenesis|
|cAMP-mediated signaling|
|positive regulation of synaptic transmission|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|vascular process in circulatory system|
|negative regulation of binding|
|cyclic-nucleotide-mediated signaling|
|regulation of cation channel activity|
|regulation of macroautophagy|
|regulation of signaling receptor activity|
|response to temperature stimulus|
|regulation of blood pressure|
|tissue homeostasis|
|regulation of ossification|
|regulation of protein ubiquitination|
|positive regulation of transmembrane transport|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|endosome membrane|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|regulation of muscle system process|
|receptor-mediated endocytosis|
|negative regulation of growth|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|lysosome|
|early endosome|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|endosome|
|positive regulation of ion transport|
|regulation of transporter activity|
|protein deubiquitination|
|protein modification by small protein removal|
|apical plasma membrane|
|multicellular organismal homeostasis|
|cellular response to peptide|
|activation of protein kinase activity|
|regulation of developmental growth|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|positive regulation of cellular catabolic process|
|regulation of binding|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|regulation of membrane potential|
|positive regulation of catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to peptide|
|regulation of ion transmembrane transport|
|response to nutrient levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|endocytosis|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|import into cell|
|regulation of ion transport|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of developmental process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|intracellular transport|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.82|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.9|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.07|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRB2 Expression in NALM6 Cells: 0.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>