ADRB2
Gene Information
- Official Symbol: ADRB2
- Official Name: adrenoceptor beta 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 154
- UniProt: P07550
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srx |
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| beta2-adrenergic receptor activity |
| positive regulation of mini excitatory postsynaptic potential |
| regulation of mini excitatory postsynaptic potential |
| norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
| desensitization of G protein-coupled receptor signaling pathway by arrestin |
| response to psychosocial stress |
| regulation of lipophagy |
| positive regulation of cAMP-dependent protein kinase activity |
| heat generation |
| positive regulation of lipophagy |
| norepinephrine binding |
| positive regulation of autophagosome maturation |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine |
| epinephrine binding |
| positive regulation of AMPA receptor activity |
| positive regulation of protein kinase A signaling |
| negative regulation of multicellular organism growth |
| regulation of autophagosome maturation |
| diet induced thermogenesis |
| activation of transmembrane receptor protein tyrosine kinase activity |
| adenylate cyclase binding |
| negative regulation of smooth muscle contraction |
| regulation of cAMP-dependent protein kinase activity |
| positive regulation of glutamate receptor signaling pathway |
| adrenergic receptor activity |
| negative regulation of systemic arterial blood pressure |
| adaptive thermogenesis |
| negative adaptation of signaling pathway |
| desensitization of G protein-coupled receptor signaling pathway |
| regulation of protein kinase A signaling |
| adaptation of signaling pathway |
| negative regulation of muscle contraction |
| adrenergic receptor signaling pathway |
| adenylate cyclase-activating adrenergic receptor signaling pathway |
| bone resorption |
| regulation of AMPA receptor activity |
| response to dietary excess |
| positive regulation of excitatory postsynaptic potential |
| brown fat cell differentiation |
| vasodilation |
| temperature homeostasis |
| positive regulation of signaling receptor activity |
| positive regulation of protein complex disassembly |
| activation of adenylate cyclase activity |
| positive regulation of bone mineralization |
| cellular response to amyloid-beta |
| modulation of excitatory postsynaptic potential |
| potassium channel regulator activity |
| negative regulation of blood pressure |
| bone remodeling |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| positive regulation of biomineralization |
| negative regulation of G protein-coupled receptor signaling pathway |
| positive regulation of biomineral tissue development |
| response to cold |
| response to amyloid-beta |
| endosome to lysosome transport |
| clathrin-coated vesicle membrane |
| positive regulation of blood vessel diameter |
| regulation of smooth muscle contraction |
| positive regulation of nervous system process |
| regulation of glutamate receptor signaling pathway |
| regulation of multicellular organism growth |
| positive regulation of macroautophagy |
| positive regulation of cation channel activity |
| regulation of bone mineralization |
| regulation of neurotransmitter receptor activity |
| amyloid-beta binding |
| positive regulation of ossification |
| regulation of sodium ion transport |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| regulation of systemic arterial blood pressure |
| positive regulation of cold-induced thermogenesis |
| tissue remodeling |
| negative regulation of protein binding |
| positive regulation of ion transmembrane transporter activity |
| negative regulation of developmental growth |
| fat cell differentiation |
| lysosomal transport |
| positive regulation of transporter activity |
| regulation of protein complex disassembly |
| positive regulation of protein ubiquitination |
| positive regulation of autophagy |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| positive regulation of protein modification by small protein conjugation or removal |
| regulation of nervous system process |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| positive regulation of cation transmembrane transport |
| vacuolar transport |
| regulation of G protein-coupled receptor signaling pathway |
| regulation of cold-induced thermogenesis |
| cAMP-mediated signaling |
| positive regulation of synaptic transmission |
| positive regulation of ion transmembrane transport |
| regulation of muscle contraction |
| vascular process in circulatory system |
| negative regulation of binding |
| cyclic-nucleotide-mediated signaling |
| regulation of cation channel activity |
| regulation of macroautophagy |
| regulation of signaling receptor activity |
| response to temperature stimulus |
| regulation of blood pressure |
| tissue homeostasis |
| regulation of ossification |
| regulation of protein ubiquitination |
| positive regulation of transmembrane transport |
| receptor complex |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| endosome membrane |
| regulation of protein binding |
| regulation of protein modification by small protein conjugation or removal |
| regulation of muscle system process |
| receptor-mediated endocytosis |
| negative regulation of growth |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| lysosome |
| early endosome |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| protein-containing complex binding |
| endosome |
| positive regulation of ion transport |
| regulation of transporter activity |
| protein deubiquitination |
| protein modification by small protein removal |
| apical plasma membrane |
| multicellular organismal homeostasis |
| cellular response to peptide |
| activation of protein kinase activity |
| regulation of developmental growth |
| regulation of autophagy |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| positive regulation of cellular catabolic process |
| regulation of binding |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| regulation of membrane potential |
| positive regulation of catabolic process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| response to peptide |
| regulation of ion transmembrane transport |
| response to nutrient levels |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| endocytosis |
| regulation of transmembrane transport |
| positive regulation of kinase activity |
| regulation of system process |
| cellular response to organonitrogen compound |
| positive regulation of organelle organization |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| regulation of growth |
| import into cell |
| regulation of ion transport |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of cellular catabolic process |
| cellular protein-containing complex assembly |
| membrane organization |
| regulation of kinase activity |
| protein homodimerization activity |
| negative regulation of developmental process |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of organelle organization |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| intracellular transport |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinate 1000μM R03 exp140 | 1.82 |
| Ribavirin 10μM R01 exp52 | 1.9 |
| Ethambutol 25μM R08 exp481 | 2.07 |
| BS-181 20μM R08 exp461 | 2.34 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17466
- Expression level (log2 read counts): 0.09
Expression Distribution
ADRB2 Expression in NALM6 Cells: 0.09
