ADRBK1 [The Human Chemical-Genetic Interaction Map Project]

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======= ADRBK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRK2
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=156|156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25098|P25098]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRBK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRBK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109635|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Pkinase Tyr|
|Pkinase|
|RGS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of the force of heart contraction by chemical signal|
|Edg-2 lysophosphatidic acid receptor binding|
|beta-adrenergic receptor kinase activity|
|alpha-2A adrenergic receptor binding|
|regulation of the force of heart contraction by chemical signal|
|G protein-coupled receptor kinase activity|
|tachykinin receptor signaling pathway|
|negative regulation of striated muscle contraction|
|positive regulation of catecholamine secretion|
|negative adaptation of signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|G protein-coupled acetylcholine receptor signaling pathway|
|adaptation of signaling pathway|
|negative regulation of muscle contraction|
|negative regulation of heart contraction|
|regulation of the force of heart contraction|
|viral genome replication|
|acetylcholine receptor signaling pathway|
|cellular response to acetylcholine|
|response to acetylcholine|
|negative regulation of blood circulation|
|positive regulation of amine transport|
|postsynaptic signal transduction|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of catecholamine secretion|
|receptor internalization|
|cardiac muscle contraction|
|peptidyl-threonine phosphorylation|
|heart contraction|
|regulation of striated muscle contraction|
|peptidyl-threonine modification|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|viral entry into host cell|
|heart process|
|entry into host cell|
|entry into host|
|receptor metabolic process|
|striated muscle contraction|
|cellular response to ammonium ion|
|regulation of G protein-coupled receptor signaling pathway|
|interaction with host|
|regulation of muscle contraction|
|peptidyl-serine phosphorylation|
|response to ammonium ion|
|cilium|
|peptidyl-serine modification|
|viral life cycle|
|regulation of muscle system process|
|receptor-mediated endocytosis|
|protein kinase activity|
|regulation of heart contraction|
|muscle contraction|
|regulation of blood circulation|
|muscle system process|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|synaptic signaling|
|heart development|
|endocytosis|
|regulation of system process|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|import into cell|
|viral process|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|circulatory system development|
|peptidyl-amino acid modification|
|response to hormone|
|protein phosphorylation|
|positive regulation of transport|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.81|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.8|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.76|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7764
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRBK1 Expression in NALM6 Cells: 8.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>