ADRBK1

Gene Information

Official Symbol: GRK2
Official Name: G protein-coupled receptor kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 156
UniProt: P25098
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7764
Expression level (log2 read counts): 8.42

Expression Distribution

Screen	Score
Oligomycin-A 2μM R00 exp25	-1.81
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.8
HMS-I2 10μM R06 exp288	1.76
Cadmium 60μM R08 exp462	1.86

PH
Pkinase Tyr
Pkinase
RGS

negative regulation of the force of heart contraction by chemical signal
Edg-2 lysophosphatidic acid receptor binding
beta-adrenergic receptor kinase activity
alpha-2A adrenergic receptor binding
regulation of the force of heart contraction by chemical signal
G protein-coupled receptor kinase activity
tachykinin receptor signaling pathway
negative regulation of striated muscle contraction
positive regulation of catecholamine secretion
negative adaptation of signaling pathway
desensitization of G protein-coupled receptor signaling pathway
G protein-coupled acetylcholine receptor signaling pathway
adaptation of signaling pathway
negative regulation of muscle contraction
negative regulation of heart contraction
regulation of the force of heart contraction
viral genome replication
acetylcholine receptor signaling pathway
cellular response to acetylcholine
response to acetylcholine
negative regulation of blood circulation
positive regulation of amine transport
postsynaptic signal transduction
negative regulation of G protein-coupled receptor signaling pathway
regulation of catecholamine secretion
receptor internalization
cardiac muscle contraction
peptidyl-threonine phosphorylation
heart contraction
regulation of striated muscle contraction
peptidyl-threonine modification
signal transduction involved in cellular response to ammonium ion
regulation of amine transport
viral entry into host cell
heart process
entry into host cell
entry into host
receptor metabolic process
striated muscle contraction
cellular response to ammonium ion