ADSS [The Human Chemical-Genetic Interaction Map Project]

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======= ADSS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADSS2
  * **<color #00a2e8>Official Name</color>**: adenylosuccinate synthase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=159|159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30520|P30520]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADSS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADSS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adenylsucc synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylosuccinate synthase activity|
|de novo AMP biosynthetic process|
|AMP biosynthetic process|
|aspartate metabolic process|
|phosphate ion binding|
|cellular response to electrical stimulus|
|IMP metabolic process|
|AMP metabolic process|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|response to electrical stimulus|
|nucleoside monophosphate biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|aspartate family amino acid metabolic process|
|nucleoside monophosphate metabolic process|
|dicarboxylic acid metabolic process|
|purine ribonucleotide biosynthetic process|
|response to purine-containing compound|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to ammonium ion|
|alpha-amino acid metabolic process|
|magnesium ion binding|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|GTP binding|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.75|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.36|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.35|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.16|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.72|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.77|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.77|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.78|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.82|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.05|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.42|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.43|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.54|
|[[:results:exp211|AICAR 240μM R05 exp211]]|5.35|
|[[:results:exp116|AICAR 240μM R03 exp116]]|7.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nudt2|NUDT2]]|0.518|
|[[:human genes:a:ak2|AK2]]|0.477|
|[[:human genes:a:adk|ADK]]|0.452|
|[[:human genes:o:ogdh|OGDH]]|0.427|
|[[:human genes:m:mmachc|MMACHC]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 26/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADSS Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>