ADSS

Entrez Summary: N/A
UniProt Summary: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 26/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	0/20
lung	4/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	5/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

adenylosuccinate synthase activity
de novo AMP biosynthetic process
AMP biosynthetic process
aspartate metabolic process
phosphate ion binding
cellular response to electrical stimulus
IMP metabolic process
AMP metabolic process
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
response to electrical stimulus
nucleoside monophosphate biosynthetic process
ribonucleoside monophosphate metabolic process
aspartate family amino acid metabolic process
nucleoside monophosphate metabolic process
dicarboxylic acid metabolic process
purine ribonucleotide biosynthetic process
response to purine-containing compound
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
response to ammonium ion
alpha-amino acid metabolic process
magnesium ion binding
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
cellular amino acid metabolic process
purine ribonucleotide metabolic process
cellular response to abiotic stimulus
cellular response to environmental stimulus
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
GTP binding
nucleotide metabolic process