ADTRP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ADTRP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADTRP
  * **<color #00a2e8>Official Name</color>**: androgen dependent TFPI regulating protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84830|84830]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96IZ2|Q96IZ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADTRP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADTRP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614348|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro). {ECO:0000269|PubMed:21868574}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Far-17a AIG1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of extracellular matrix constituent secretion|
|regulation of extracellular matrix constituent secretion|
|long-chain fatty acid catabolic process|
|cellular response to oxidised low-density lipoprotein particle stimulus|
|negative regulation of extracellular matrix organization|
|negative regulation of lymphocyte migration|
|cell migration involved in sprouting angiogenesis|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|blood vessel endothelial cell migration|
|protein kinase B signaling|
|regulation of extracellular matrix organization|
|negative regulation of leukocyte migration|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|sprouting angiogenesis|
|regulation of lymphocyte migration|
|endothelial cell migration|
|negative regulation of wound healing|
|caveola|
|hydrolase activity|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|epithelial cell migration|
|negative regulation of response to wounding|
|epithelium migration|
|tissue migration|
|fatty acid catabolic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of protein secretion|
|regulation of wound healing|
|negative regulation of peptide secretion|
|regulation of response to wounding|
|ameboidal-type cell migration|
|negative regulation of cell-cell adhesion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|cellular response to steroid hormone stimulus|
|cellular lipid catabolic process|
|regulation of leukocyte migration|
|negative regulation of secretion by cell|
|negative regulation of secretion|
|negative regulation of cell migration|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|regulation of leukocyte cell-cell adhesion|
|lipid catabolic process|
|negative regulation of cellular component movement|
|angiogenesis|
|negative regulation of locomotion|
|fatty acid metabolic process|
|response to steroid hormone|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|blood vessel morphogenesis|
|small molecule catabolic process|
|negative regulation of immune system process|
|regulation of protein secretion|
|negative regulation of transport|
|blood vessel development|
|regulation of peptide secretion|
|regulation of body fluid levels|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|cell surface|
|tube morphogenesis|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|organic acid metabolic process|
|regulation of protein localization|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|locomotion|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADTRP Expression in NALM6 Cells: 0.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>