ADTRP
Gene Information
- Official Symbol: ADTRP
- Official Name: androgen dependent TFPI regulating protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 84830
- UniProt: Q96IZ2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro). {ECO:0000269|PubMed:21868574}.
Pfam Domains GO Terms
Pfam Domains
| Far-17a AIG1 |
GO Terms
| negative regulation of extracellular matrix constituent secretion |
| regulation of extracellular matrix constituent secretion |
| long-chain fatty acid catabolic process |
| cellular response to oxidised low-density lipoprotein particle stimulus |
| negative regulation of extracellular matrix organization |
| negative regulation of lymphocyte migration |
| cell migration involved in sprouting angiogenesis |
| response to lipoprotein particle |
| cellular response to lipoprotein particle stimulus |
| blood vessel endothelial cell migration |
| protein kinase B signaling |
| regulation of extracellular matrix organization |
| negative regulation of leukocyte migration |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| sprouting angiogenesis |
| regulation of lymphocyte migration |
| endothelial cell migration |
| negative regulation of wound healing |
| caveola |
| hydrolase activity |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| epithelial cell migration |
| negative regulation of response to wounding |
| epithelium migration |
| tissue migration |
| fatty acid catabolic process |
| long-chain fatty acid metabolic process |
| monocarboxylic acid catabolic process |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of protein secretion |
| regulation of wound healing |
| negative regulation of peptide secretion |
| regulation of response to wounding |
| ameboidal-type cell migration |
| negative regulation of cell-cell adhesion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| cellular response to steroid hormone stimulus |
| cellular lipid catabolic process |
| regulation of leukocyte migration |
| negative regulation of secretion by cell |
| negative regulation of secretion |
| negative regulation of cell migration |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| regulation of leukocyte cell-cell adhesion |
| lipid catabolic process |
| negative regulation of cellular component movement |
| angiogenesis |
| negative regulation of locomotion |
| fatty acid metabolic process |
| response to steroid hormone |
| negative regulation of response to external stimulus |
| regulation of cell-cell adhesion |
| blood vessel morphogenesis |
| small molecule catabolic process |
| negative regulation of immune system process |
| regulation of protein secretion |
| negative regulation of transport |
| blood vessel development |
| regulation of peptide secretion |
| regulation of body fluid levels |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| monocarboxylic acid metabolic process |
| cellular response to organic cyclic compound |
| cellular response to hormone stimulus |
| cell surface |
| tube morphogenesis |
| regulation of cell adhesion |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| tube development |
| regulation of cell migration |
| response to lipid |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| carboxylic acid metabolic process |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| oxoacid metabolic process |
| positive regulation of protein phosphorylation |
| organic acid metabolic process |
| regulation of protein localization |
| positive regulation of phosphorylation |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| regulation of response to external stimulus |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| locomotion |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18561
- Expression level (log2 read counts): 0.56
Expression Distribution
ADTRP Expression in NALM6 Cells: 0.56
