AEN

Entrez Summary: N/A
UniProt Summary: Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

exonuclease activity
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
intrinsic apoptotic signaling pathway by p53 class mediator
intrinsic apoptotic signaling pathway in response to DNA damage
signal transduction by p53 class mediator
response to ionizing radiation
intrinsic apoptotic signaling pathway
nucleic acid binding
nuclear membrane
apoptotic signaling pathway
nucleic acid phosphodiester bond hydrolysis
response to radiation
cellular response to DNA damage stimulus
nucleolus
apoptotic process
programmed cell death
cell death
response to abiotic stimulus
intracellular signal transduction
cellular response to stress