AFAP1L2

Gene Information

Official Symbol: AFAP1L2
Official Name: actin filament associated protein 1 like 2
Aliases and Previous Symbols: N/A
Entrez ID: 84632
UniProt: Q8N4X5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5182
Expression level (log2 read counts): -1.56

Expression Distribution

protein tyrosine kinase activator activity
signaling adaptor activity
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERBB signaling pathway
SH2 domain binding
positive regulation of interleukin-8 production
positive regulation of protein tyrosine kinase activity
regulation of interleukin-8 production
regulation of epidermal growth factor receptor signaling pathway
regulation of protein tyrosine kinase activity
regulation of ERBB signaling pathway
SH3 domain binding
regulation of interleukin-6 production
positive regulation of peptidyl-tyrosine phosphorylation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of cytokine production
inflammatory response
positive regulation of protein kinase activity
positive regulation of kinase activity
regulation of mitotic cell cycle
positive regulation of transferase activity
regulation of cytokine production
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
regulation of cell cycle
positive regulation of protein modification process
defense response
positive regulation of catalytic activity
regulation of protein phosphorylation
positive regulation of transcription, DNA-templated
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction