AFMID

Entrez Summary: N/A
UniProt Summary: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255|HAMAP-Rule:MF_03014}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Abhydrolase 5
Abhydrolase 3

arylformamidase activity
tryptophan catabolic process to kynurenine
de novo NAD biosynthetic process from tryptophan
de novo NAD biosynthetic process
tryptophan catabolic process
indolalkylamine catabolic process
indole-containing compound catabolic process
kynurenine metabolic process
tryptophan metabolic process
indolalkylamine metabolic process
cellular biogenic amine catabolic process
amine catabolic process
indole-containing compound metabolic process
benzene-containing compound metabolic process
aromatic amino acid family catabolic process
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
pyridine-containing compound biosynthetic process
aromatic amino acid family metabolic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
cellular ketone metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
coenzyme biosynthetic process
alpha-amino acid metabolic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
heterocycle catabolic process