AGFG1 [The Human Chemical-Genetic Interaction Map Project]

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======= AGFG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGFG1
  * **<color #00a2e8>Official Name</color>**: ArfGAP with FG repeats 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3267|3267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52594|P52594]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGFG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGFG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600862|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ArfGap|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acrosome assembly|
|spermatid nucleus differentiation|
|intermediate filament organization|
|secretory granule organization|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|nuclear pore|
|cell projection|
|cellular component assembly involved in morphogenesis|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|nucleus organization|
|protein export from nucleus|
|spermatid development|
|mRNA transport|
|spermatid differentiation|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|cytoplasmic vesicle|
|protein-containing complex localization|
|germ cell development|
|nucleocytoplasmic transport|
|nuclear transport|
|GTPase activator activity|
|vesicle organization|
|cellular process involved in reproduction in multicellular organism|
|neuronal cell body|
|positive regulation of GTPase activity|
|endomembrane system organization|
|supramolecular fiber organization|
|regulation of GTPase activity|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|gamete generation|
|organelle assembly|
|positive regulation of hydrolase activity|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|multi-organism reproductive process|
|intracellular protein transport|
|cytoskeleton organization|
|regulation of hydrolase activity|
|RNA binding|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|DNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.79|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc39a9|SLC39A9]]|0.45|
|[[:human genes:s:sh3gl1|SH3GL1]]|0.447|
|[[:human genes:v:vps45|VPS45]]|0.435|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGFG1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>