AGFG1
Gene Information
- Official Symbol: AGFG1
- Official Name: ArfGAP with FG repeats 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3267
- UniProt: P52594
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ArfGap |
GO Terms
| acrosome assembly |
| spermatid nucleus differentiation |
| intermediate filament organization |
| secretory granule organization |
| intermediate filament cytoskeleton organization |
| intermediate filament-based process |
| nuclear pore |
| cell projection |
| cellular component assembly involved in morphogenesis |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| nucleus organization |
| protein export from nucleus |
| spermatid development |
| mRNA transport |
| spermatid differentiation |
| nuclear export |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| RNA localization |
| nucleobase-containing compound transport |
| cytoplasmic vesicle |
| protein-containing complex localization |
| germ cell development |
| nucleocytoplasmic transport |
| nuclear transport |
| GTPase activator activity |
| vesicle organization |
| cellular process involved in reproduction in multicellular organism |
| neuronal cell body |
| positive regulation of GTPase activity |
| endomembrane system organization |
| supramolecular fiber organization |
| regulation of GTPase activity |
| spermatogenesis |
| male gamete generation |
| developmental process involved in reproduction |
| intracellular membrane-bounded organelle |
| gamete generation |
| organelle assembly |
| positive regulation of hydrolase activity |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| membrane organization |
| anatomical structure formation involved in morphogenesis |
| multi-organism reproductive process |
| intracellular protein transport |
| cytoskeleton organization |
| regulation of hydrolase activity |
| RNA binding |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| DNA binding |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cell development |
| positive regulation of molecular function |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lead acetate 2000μM R08 exp497 | 1.74 |
| QNZ 0.01μM R08 exp439 | 1.79 |
| BI-6727 0.0125μM R03 exp97 | 1.92 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12777
- Expression level (log2 read counts): 6.37
Expression Distribution
AGFG1 Expression in NALM6 Cells: 6.37
