AGPAT3

Entrez Summary: N/A
UniProt Summary: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity). {ECO:0000250|UniProtKB:Q9D517, ECO:0000269|PubMed:21173190}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Aminopterin 0.005μM R07 exp335	1.81
Vemurafenib 6.6μM R02 exp89	1.97

CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
transferase activity, transferring acyl groups
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine-containing compound metabolic process
nuclear envelope
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
Golgi membrane
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
lipid metabolic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process
membrane