AGPS [The Human Chemical-Genetic Interaction Map Project]

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======= AGPS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGPS
  * **<color #00a2e8>Official Name</color>**: alkylglycerone phosphate synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8540|8540]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00116|O00116]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGPS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGPS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD-oxidase C|
|FAD binding 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alkylglycerone-phosphate synthase activity|
|ether lipid biosynthetic process|
|ether biosynthetic process|
|glycerol ether biosynthetic process|
|cellular lipid biosynthetic process|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|ether metabolic process|
|FAD binding|
|peroxisomal matrix|
|peroxisomal membrane|
|establishment of protein localization to peroxisome|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|peroxisome|
|oxidoreductase activity|
|protein targeting|
|establishment of protein localization to organelle|
|lipid biosynthetic process|
|protein localization to organelle|
|nucleolus|
|cellular lipid metabolic process|
|oxidation-reduction process|
|intracellular protein transport|
|lipid metabolic process|
|mitochondrion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-3.01|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.34|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.31|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.02|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.01|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.98|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.96|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.77|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.72|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.7|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.522|
|[[:human genes:p:prim1|PRIM1]]|0.508|
|[[:human genes:p:pex1|PEX1]]|0.507|
|[[:human genes:g:gnpat|GNPAT]]|0.496|
|[[:human genes:p:pex2|PEX2]]|0.477|
|[[:human genes:p:pex12|PEX12]]|0.473|
|[[:human genes:p:pex7|PEX7]]|0.472|
|[[:human genes:f:far1|FAR1]]|0.457|
|[[:human genes:p:pex13|PEX13]]|0.452|
|[[:human genes:t:tmem189|TMEM189]]|0.451|
|[[:human genes:p:pex6|PEX6]]|0.445|
|[[:human genes:p:pex10|PEX10]]|0.444|
|[[:human genes:p:pex14|PEX14]]|0.423|
|[[:human genes:p:pex5|PEX5]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4636
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGPS Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>