AGPS

Entrez Summary: This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-3.01
THZ531 0.225μM R08 exp444	-2.34
Oligomycin-A 20μM R00 exp26	-2.31
CCT251545 0.2μM R06 exp271	-2.02
Monensin 0.3μM R08 exp507	-2.01
Nocodazole 0.02μM R00 exp23	-1.98
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.96
MLN-4924 2μM R00 exp22	-1.77
Nocodazole 0.2μM R02 exp64	-1.72
WYE-354 6μM R02 exp90	1.7
Cerivastatin 0.15μM R05 exp226	2.19

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FAD-oxidase C
FAD binding 4

alkylglycerone-phosphate synthase activity
ether lipid biosynthetic process
ether biosynthetic process
glycerol ether biosynthetic process
cellular lipid biosynthetic process
ether lipid metabolic process
glycerol ether metabolic process
ether metabolic process
FAD binding
peroxisomal matrix
peroxisomal membrane
establishment of protein localization to peroxisome
protein targeting to peroxisome
protein localization to peroxisome
peroxisomal transport
peroxisome organization
peroxisome
oxidoreductase activity
protein targeting
establishment of protein localization to organelle
lipid biosynthetic process
protein localization to organelle
nucleolus
cellular lipid metabolic process
oxidation-reduction process
intracellular protein transport
lipid metabolic process
mitochondrion
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
small molecule metabolic process
establishment of localization in cell
nitrogen compound transport
membrane