AGT

Gene Information

Official Symbol: AGT
Official Name: angiotensinogen
Aliases and Previous Symbols: N/A
Entrez ID: 183
UniProt: P01019
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008].
UniProt Summary: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-3: stimulates aldosterone release.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6164
Expression level (log2 read counts): -6.6

Expression Distribution

type 2 angiotensin receptor binding
positive regulation of L-lysine import across plasma membrane
regulation of L-lysine import across plasma membrane
regulation of L-arginine import across plasma membrane
positive regulation of L-arginine import across plasma membrane
uterine smooth muscle contraction
fibroblast proliferation
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
angiotensin-mediated drinking behavior
regulation of L-arginine import
brain renin-angiotensin system
positive regulation of gap junction assembly
operant conditioning
positive regulation of extracellular matrix constituent secretion
response to muscle activity involved in regulation of muscle adaptation
regulation of renal output by angiotensin
smooth muscle cell proliferation
negative regulation of neurotrophin TRK receptor signaling pathway
renin-angiotensin regulation of aldosterone production
regulation of gap junction assembly
regulation of blood vessel diameter by renin-angiotensin
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
regulation of aldosterone secretion
regulation of mineralocorticoid secretion
type 1 angiotensin receptor binding
regulation of extracellular matrix constituent secretion
positive regulation of activation of Janus kinase activity
positive regulation of NAD(P)H oxidase activity
positive regulation of anion transmembrane transport
regulation of blood volume by renin-angiotensin
regulation of amino acid transmembrane transport
regulation of amino acid import across plasma membrane
cell growth involved in cardiac muscle cell development
positive regulation of cholesterol esterification
regulation of activation of Janus kinase activity
physiological muscle hypertrophy
regulation of extracellular matrix assembly
physiological cardiac muscle hypertrophy
drinking behavior
artery smooth muscle contraction