AHSG

Entrez Summary: The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017].
UniProt Summary: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

kinase inhibitor activity
pinocytosis
negative regulation of bone mineralization
negative regulation of biomineralization
negative regulation of biomineral tissue development
cysteine-type endopeptidase inhibitor activity
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
acute-phase response
regulation of insulin receptor signaling pathway
platelet alpha granule lumen
positive regulation of phagocytosis
acute inflammatory response
regulation of cellular response to insulin stimulus
negative regulation of ossification
regulation of bone mineralization
regulation of biomineral tissue development
regulation of biomineralization
regulation of phagocytosis
secretory granule lumen
platelet degranulation
blood microparticle
regulation of ossification
negative regulation of endopeptidase activity
negative regulation of kinase activity
negative regulation of peptidase activity
negative regulation of transferase activity
endoplasmic reticulum lumen
regulation of inflammatory response
negative regulation of proteolysis
post-translational protein modification
collagen-containing extracellular matrix
regulation of endopeptidase activity
negative regulation of phosphorylation
regulation of peptidase activity
negative regulation of hydrolase activity
neutrophil degranulation
neutrophil activation involved in immune response
skeletal system development
inflammatory response